Two years after Bangkok, Leslie Chow (Ken Jeong) escapes from a maximum security prison, using a riot as cover. Meanwhile in America, Alan Garner (Zach Galifianakis) causes a 20-car freeway pileup after he purchases a giraffe and accidentally decapitates it on a low bridge. Alan's father (Jeffrey Tambor), furious with Alan for never owning up to his mistakes, dies of a heart attack. After the funeral, Alan's brother-in-law Doug Billings (Justin Bartha) informs friends Phil Wenneck (Bradley Cooper) and Stu Price (Ed Helms) that Alan has been off his ADHD medication and is out of control. They attend an intervention, in which Alan agrees to visit a rehab facility in Arizona, so long as "the Wolfpack" takes him there. On the way to Arizona, Phil's minivan is rammed off the road by a rental truck and the group is taken hostage. They are later confronted by mob leader Marshall (John Goodman) and "Black Doug" (Mike Epps), his head of security. He tells them that Chow hijacked half of a $42 million gold heist and, seeing how Alan has been the only one to communicate with Chow during his imprisonment, deduced that the Wolfpack could locate him and retrieve the gold. Marshall takes Doug as collateral and gives the others three days to find Chow.
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